Structure of PDB 6oon Chain A

Receptor sequence
>6oonA (length=785) Species: 9606 (Homo sapiens) [Search protein sequence]
LFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVN
REVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLQT
FKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPV
GRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRA
QPIIEFMCEVLDIQNIKPLTDSQRVKFTKEIRGLKVEVRKYRVCNVTRRP
ASHQTFPLMECTVAQYFKQKYSLQLKYPHLPCLQVTYLPLEVCNIVAGQR
CIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSPDPYLKEFGIVVHNEM
TELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVAC
FAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMF
KHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKT
SPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPKKP
SIAAVVGSMDGHPSRYCATVRVQTYSQEVIQDLTNMVRELLIQFYKSTRF
KPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQK
RHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGT
SRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLV
AFRARYHLVDKDRDPQALAKAVQIHHDTQHTMYFA
3D structure
PDB6oon Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0035198 miRNA binding
GO:0061980 regulatory RNA binding
Biological Process
GO:0006402 mRNA catabolic process
GO:0006417 regulation of translation
GO:0007130 synaptonemal complex assembly
GO:0007140 male meiotic nuclear division
GO:0008584 male gonad development
GO:0010501 RNA secondary structure unwinding
GO:0010586 miRNA metabolic process
GO:0022604 regulation of cell morphogenesis
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0031054 pre-miRNA processing
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0035196 miRNA processing
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
GO:0043066 negative regulation of apoptotic process
GO:0070922 RISC complex assembly
GO:0090625 siRNA-mediated gene silencing by mRNA destabilization
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016442 RISC complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043232 intracellular non-membrane-bounded organelle
GO:0070578 RISC-loading complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6oon, PDBe:6oon, PDBj:6oon
PDBsum6oon
PubMed31324450
UniProtQ9HCK5|AGO4_HUMAN Protein argonaute-4 (Gene Name=AGO4)

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