Structure of PDB 6ome Chain A

Receptor sequence

>6omeA (length=499) Species: 272561 (Chlamydia trachomatis D/UW-3/CX)

VVLLYSQASWDQRSKADALVLPFWMKNSKAQEAAVVDEDYKLVYQNALSN
FSGKKGETAFLFGNDHTKEQKIVLLGLGKSEEVSGTTVLEAYAQATTVLR
KAKCKTVNILFPTISQLRFSVEEFLTNLAAGVLSLNYNYPTYHKVDTSLP
FLEKVTVIGIVSKVGDKIFRKEESLFEGVYLTRDLVNTNADEVTPEKLAA
VAKGLAGEFASLDVKILDRKAILKEKMGLLAAVAKGAAVEPRFIVLDYQG
KPKSKDRTVLIGKGVTFDSGGLDLKPGKAMITMKEDMAGAATVLGIFSAL
ASLELPINVTGIIPATENAIGSAAYKMGDVYVGMTGLSVEIGSTDAEGRL
ILADAISYALKYCNPTRIIDFATLTGAMVVSLGESVAGFFANNDVLARDL
AEASSETGEALWRMPLVEKYDQALHSDIADMKNIGSNRAGSITAALFLQR
FLEDNPVAWAHLDIAGTAYHEKEELPYPKYATGFGVRCLIHYMEKFLSK

3D structure

• PDB: 6ome Crystal structure of a probable cytosol aminopeptidase (Leucine aminopeptidase, LAP) from Chlamydia trachomatis D/UW-3/Cx
• Chain: A
• Resolution: 1.95 Å

Enzymatic activity

• Enzyme Commision number: 3.4.11.1: leucyl aminopeptidase.
  3.4.11.10: bacterial leucyl aminopeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CO3	A	A346 G348 R349 L374	A346 G348 R349 L374
BS02	ZN	A	K263 D268 D286 E347	K263 D268 D286 E347
BS03	ZN	A	D268 D345 E347	D268 D345 E347

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008233 peptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019538 protein metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6ome, PDBe:6ome, PDBj:6ome
• PDBsum: 6ome
• UniProt: O84049|AMPA_CHLTR Probable cytosol aminopeptidase (Gene Name=pepA)