Structure of PDB 6ol8 Chain A

Receptor sequence
>6ol8A (length=240) Species: 562 (Escherichia coli) [Search protein sequence]
IRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIV
RDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMD
ALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPL
KVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLDDADTEHYA
ASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
3D structure
PDB6ol8 Flexible loops of New Delhi metallo-beta-lactamase modulate its activity towards different substrates.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H120 H122 D124 H189 C208 K211 N220 H250
Catalytic site (residue number reindexed from 1) H90 H92 D94 H159 C178 K181 N190 H220
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H120 H122 H189 H90 H92 H159
BS02 ZN A D124 C208 H250 D94 C178 H220
BS03 ZZ7 A L65 M67 W93 H122 Q123 D124 H189 C208 K211 G219 N220 H250 L35 M37 W63 H92 Q93 D94 H159 C178 K181 G189 N190 H220
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6ol8, PDBe:6ol8, PDBj:6ol8
PDBsum6ol8
PubMed32353499
UniProtA0A024FRL9

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