Structure of PDB 6oko Chain A

Receptor sequence
>6okoA (length=263) Species: 10090 (Mus musculus) [Search protein sequence]
VPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVK
AMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPR
PWPLLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFG
TLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDQSRPPLT
ELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKDK
VDAAVSEVKHYLS
3D structure
PDB6oko Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D143 K145 S147 N148 D161 T187
Catalytic site (residue number reindexed from 1) D130 K132 S134 N135 D148 T151
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1FN A V36 A49 K51 E61 M65 F97 M98 L150 A160 D161 F162 V23 A36 K38 E48 M52 F84 M85 L137 A147 D148 F149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6oko, PDBe:6oko, PDBj:6oko
PDBsum6oko
PubMed32184955
UniProtQ9QZL0|RIPK3_MOUSE Receptor-interacting serine/threonine-protein kinase 3 (Gene Name=Ripk3)

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