Structure of PDB 6ojf Chain A

Receptor sequence
>6ojfA (length=188) Species: 9606 (Homo sapiens) [Search protein sequence]
YNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIR
DKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAM
KPWLFNIKARASSSPVILVGTHLDVSDEAQRAACMSKITKELLNKRGFPA
IRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVV
3D structure
PDB6ojf Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G1344 S1345 G1346 K1347 T1348 T1349 H1453 D1455 N1489 A1490 T1491 G13 S14 G15 K16 T17 T18 H122 D124 N158 A159 T160
BS02 MG A M1409 T1410 Y1415 M78 T79 Y84
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6ojf, PDBe:6ojf, PDBj:6ojf
PDBsum6ojf
PubMed
UniProtQ5S007|LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (Gene Name=LRRK2)

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