Structure of PDB 6oiu Chain A

Receptor sequence

>6oiuA (length=890) Species: 508771 (Toxoplasma gondii ME49)

PVEKHRLDYKPTDFLIDFVDLDFDLYDDRTKVTSTLTMHRREQTPPTDLV
LDGEDLELESVELDGNALSMHSTETQKGDKRVYSLDVDGRLVIAADLLPQ
EAEKKFKVKTVVYVRPKENLQLMGLYKSGALLVTQCEAEGFRRITYFLDR
PDVMSLFKVRLAADEKACPVLLSNGNMVESGKVEGEKGRHFAVFEDPFQK
PCYLFALVAGDLKSISQSFTTMSGRNVKVSIFSEPEDSSKLTWALESVLK
SMKWDEERFGREYDLDVFNVVCAKDFNMGAMENKGLNIFNAALLLADPST
TTDAEYQRILNVVGHEYFHQWTGNRVTCRDWFQLTLKEGLTVFRDQLFTA
DMCSAAVKRIEDVVFLRSRQFAEDSGPMAHPIRPETYIAMDNFYTATVYD
KGAEVIRMYHTLLGEAGFRKGMDLYFKRHDGKAVTCDDFRAAMADANGRD
LGQFERWYLQAGTPEVTVSEAVFQPDRKKFKLTLKQRTPPTPGQVEKHPF
HIPIKVGLIGKTSKKDILSPPTKVLELTEAEQTFELDAAEDCVLSFLRDF
SAPVKVKHEQTDEDIAFLMAHDSDDFAKWQAAHTLASGLLKHRAEQWREK
QGEDVEFARLPKIYVEAFKQTLLEQGRDRSIQAYTLRLPDRDGVAQEMEP
IDPLALKEATESVRREVGQLLKSDLLKVYASLSAESRDQSEVSRRRLRNV
ILYFLTGERDKEAAALAMNHFKSAKGMTEKYAALSILCDIEGPERTAALE
QFYRDAKGDPLVLDKWFAVQALSDVRQVTETVKELQKHADFTAKNPNRLR
ALIFSFTRNPQFHNKDGAGYALLADSVLAVDRFNPQIAARGAGAFLQWKK
YDETRQREMLKQLRRIANAPGLSVDTLEIVQKALAGAPEE

3D structure

• PDB: 6oiu X-ray crystal structure and specificity of the Toxoplasma gondii ME49 TgAPN2.
• Chain: A
• Resolution: 2.2 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): E802 H835 E836 H839 E858 D911 Y919
• Catalytic site (residue number reindexed from 1): E282 H315 E316 H319 E338 D391 Y399
• Enzyme Commision number: 3.4.11.2: membrane alanyl aminopeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H835 H839 E858	H315 H319 E338

Gene Ontology

Molecular Function

• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:6oiu, PDBe:6oiu, PDBj:6oiu
• PDBsum: 6oiu
• PubMed: 32926129
• UniProt: S8G5K8