Structure of PDB 6oir Chain A

Receptor sequence
>6oirA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
KYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFH
LGQCQWRQPPGKEIYRKSNISVHEVDGKDHKIYCQNLCLLAKLFLDHKTL
YFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVSCIMILPPYQRR
GYGRFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLENLRDF
RGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHL
KSAQYKKPPITVDSVCLKWAPP
3D structure
PDB6oir Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A.
ChainA
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C540 C543 H556 C560 C34 C37 H50 C54
BS02 MNJ A L601 I649 Q654 R655 G657 G659 R660 S684 L686 S690 L95 I143 Q148 R149 G151 G153 R154 S178 L180 S184 PDBbind-CN: -logKd/Ki=7.77,IC50=0.017uM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6oir, PDBe:6oir, PDBj:6oir
PDBsum6oir
PubMed31256587
UniProtQ9H7Z6|KAT8_HUMAN Histone acetyltransferase KAT8 (Gene Name=KAT8)

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