Structure of PDB 6oio Chain A

Receptor sequence
>6oioA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
VKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRF
HLGQCQWRQPPGKEIYRKSNISVHEVDGKDHKIYCQNLCLLAKLFLDHKT
LYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVSCIMILPPYQR
RGYGRFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLENLRD
FRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEH
LKSAQYKKPPITVDSVCLKWAPP
3D structure
PDB6oio Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ML7 A L601 I649 Q654 R655 G657 G659 R660 S684 S690 S693 L96 I144 Q149 R150 G152 G154 R155 S179 S185 S188 PDBbind-CN: -logKd/Ki=6.54,IC50=0.29uM
BS02 ZN A C540 C543 H556 C560 C35 C38 H51 C55
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6oio, PDBe:6oio, PDBj:6oio
PDBsum6oio
PubMed31256587
UniProtQ9H7Z6|KAT8_HUMAN Histone acetyltransferase KAT8 (Gene Name=KAT8)

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