Structure of PDB 6oi6 Chain A

Receptor sequence

>6oi6A (length=407) Species: 9606 (Homo sapiens)

MNHYEVLVLGGGSGGITMAARMKRKVGAENVAIVEPSERHFYQPIWTLVG
AGAKQLSSSGRPTASVIPSGVEWIKARVTELNPDKNCIHTDDDEKISYRY
LIIALGIQLDYEKIKGLPEGFAHPKIGSNYSVKTVEKTWKALQDFKEGNA
IFTFPNTPVKCAGAPQKIMYLSEAYFRKTGKRSKANIIFNTSLGAIFGVK
KYADALQEIIQERNLTVNYKKNLIEVRADKQEAVFENLDKPGETQVISYE
MLHVTPPMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGDCTNL
PTSKTAAAVAAQSGILDRTISVIMKNQTPTKKYDGYTSCPLVTGYNRVIL
AEFDYKAEPLETFPFDQSKERLSMYLMKADLMPFLYWNMMLRGYWGGPAF
LRKLFHL

3D structure

• PDB: 6oi6 A Catalytic Trisulfide in Human Sulfide Quinone Oxidoreductase Catalyzes Coenzyme A Persulfide Synthesis and Inhibits Butyrate Oxidation.
• Chain: A
• Resolution: 2.56 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K173 C201 I389 E392 K418
• Catalytic site (residue number reindexed from 1): K133 C161 I349 E352 K378
• Enzyme Commision number: 1.8.5.8: eukaryotic sulfide quinone oxidoreductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G52 S53 G54 E75 P76 Q83 P84 R117 V118 L145 G146 Y170 C201 D336 T345 A346 P380	G12 S13 G14 E35 P36 Q43 P44 R77 V78 L105 G106 Y130 C161 D296 T305 A306 P340
BS02	UQ1	A	G436 F440	G396 F400
BS03	UQ1	A	Q247 Q251 V257	Q207 Q211 V217

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0016491 oxidoreductase activity
• GO:0048038 quinone binding
• GO:0070224 sulfide:quinone oxidoreductase activity
• GO:0071949 FAD binding
• GO:0106436 glutathione-dependent sulfide quinone oxidoreductase activity

Biological Process

• GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane

External links

• PDB: RCSB:6oi6, PDBe:6oi6, PDBj:6oi6
• PDBsum: 6oi6
• PubMed: 31591036
• UniProt: Q9Y6N5|SQOR_HUMAN Sulfide:quinone oxidoreductase, mitochondrial (Gene Name=SQOR)