Structure of PDB 6ohm Chain A

Receptor sequence
>6ohmA (length=574) Species: 9606 (Homo sapiens) [Search protein sequence]
DFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWW
LSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELGINSGYSK
RALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDD
LHYRLTDLGPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPR
MPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSPG
GQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCS
DGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNS
IQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHP
VSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEP
SLMNGAEYQAGRFALSLRKHCFGVILGPDLDLRDPICDDFFQLWQDMAES
NANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGH
LVHFPLKFLEDESLLGMIPLEVWT
3D structure
PDB6ohm Human PLD structures enable drug design and characterization of isoenzyme selectivity.
ChainA
Resolution1.895 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.4: phospholipase D.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WO4 A H442 K444 Q642 H756 K758 N773 H125 K127 Q294 H408 K410 N425
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004630 phospholipase D activity
Biological Process
GO:0006654 phosphatidic acid biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6ohm, PDBe:6ohm, PDBj:6ohm
PDBsum6ohm
PubMed32042197
UniProtO14939|PLD2_HUMAN Phospholipase D2 (Gene Name=PLD2)

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