Structure of PDB 6oha Chain A

Receptor sequence
>6ohaA (length=451) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
DKHGKFLVFFGTFVDTPKLGELRIREKTSVGVLNGIIRFVNRNSLDPVKD
CLDHDSSLSPEDVTVVDINNSFYFPGFVDTHNHVSQYPNVGVFGNSTLLD
WLEKYTFPIEAALANENIAREVYNKVISKTLSHGTTTVAYYNTIDLKSTK
LLAQLSSLLGQRVLVGKVCMDTNGPEYYIEDTKTSFESTVKVVKYIRETI
CDPLVNPIVTPRFAPSCSRELMQQLSKLVKDENIHVQTHLSENKEEIQWV
QDLFPECESYTDVYDKYGLLTEKTVLAHCIHLTDAEARVIKQRRCGISHC
PISNSSLTSGECRVRWLLDQGIKVGLGTDVSAGHSCSILTTGRQAFAVSR
HLAMRETDHAKLSVSECLFLATMGGAQVLRMDETLGTFDVGKQFDAQMID
TNAPGSNVDMFHWQLNPPLLTNEDIIAKWFFNGDDRNTTKVWVAGQQVYQ
I
3D structure
PDB6oha Structural Determinants for Substrate Selectivity in Guanine Deaminase Enzymes of the Amidohydrolase Superfamily.
ChainA
Resolution2.21 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.4.3: guanine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XAN A H102 L117 W120 R231 F232 H258 E261 H297 D348 H83 L98 W101 R212 F213 H239 E242 H278 D329
BS02 ZN A H100 H102 H258 D348 H81 H83 H239 D329
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008892 guanine deaminase activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
Biological Process
GO:0006147 guanine catabolic process
GO:0046098 guanine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6oha, PDBe:6oha, PDBj:6oha
PDBsum6oha
PubMed31283204
UniProtQ07729|GUAD_YEAST Probable guanine deaminase (Gene Name=GUD1)

[Back to BioLiP]