Structure of PDB 6ogz Chain A

Receptor sequence

>6ogzA (length=1082) Species: 28875 (Rotavirus A)

GKYNLILSEYLSFIYNSQSAVQIPIYYSSNSELENRCIEFHSKCLENSKN
GLSLKKLFVEYSDVIENATLLSILSYSYDKYNAVERKLVKYAKGKPLEAD
LTVNELDYENNKITSELFPTAEEYTDLLMDPAILTSLSSNLNAVMFWLEK
HENDVAEKLKIYKRRLDLFTIVASTVNKYGVPRHNAKYRYEYEVMKDKPY
YLVTWANSSIEMLMSVFSHEDYLIARELIVLSYSNRSTLAKLVSSPMSIL
VALVDINGTFITNEELELEFSNKYVRAIVPDQTFDELKQMLDNMRKAGLT
DIPKMIQDWLVDCSIEKFPLMAKIYSWSFHVGFRKQKMLDAALDQLKTEY
TEDVDDEMYREYTMLIRDEVVKMLEEPVKHDDHLLQDSELAGLLSMSSAS
NGESRQLKFGRKTIFSTKKNMHVMDDMANGRYTPGIIPPVNVDKPIPLGR
RDVPGRRTRIIFILPYEYFIAQHAVVEKMLIYAKHTREYAEFYSQSNQLL
SYGDVTRFLSNNSMVLYTDVSQWDSSQHNTQPFRKGIIMGLDMLANMTND
ARVIQTLNLYKQTQINLMDSYVQIPDGNVIKKIQYGAVASGEKQTKAANS
IANLALIKTVLSRISNKYSFATKIIRVDGDDNYAVLQFNTEVTKQMVQDV
SNDVRETYARMNTKVKALVSTVGIEIAKRYIAGGKIFFRAGINLLNNEKK
GQSTQWDQAAVLYSNYIVNRLRGFETDREFILTKIMQMTSVAITGSLRLF
PSERVLTTNSTFKVFDSEDFIIEYGTTDDEVYIQRAFMSLSSQKSGIADE
IAASSTFKNYVSRLSEQLLFSKNNIVSRGIALTEKAKLNSYAPISLEKRR
AQISALLTMLQKPVTFKSSKITINDILRDIKPFFTVNEAHLPIQYQKFMP
TLPDNVQYIIQCIGSRTYQIEDDGSKSAISRLISKYSVYKPSIEELYKVI
SLHENEIQLYLISLGIPKIDADTYVGSKIYSQDKYRILESYVYNLLSINY
GCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEVINHAIKNGSW
ISLFCNYPKSEMIKLWKKMWNITSLRSPYTNA

3D structure

• PDB: 6ogz In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release.
• Chain: A
• Resolution: 3.6 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	I482 D632 K679 R690 I693 R723 A837 K838 S841 R932 I944 Q983	I481 D631 K678 R689 I692 R722 A836 K837 S840 R931 I943 Q982
BS02	rna	A	A400 S401 F416 T418 I462 F463 K485 S495 Q496 S497 G592 E593 K594 K597 K701 T762 S792 S793 N1000	A399 S400 F415 T417 I461 F462 K484 S494 Q495 S496 G591 E592 K593 K596 K700 T761 S791 S792 N999
BS03	UTP	A	R457 R460 S522 Q523 D525 S591 D631	R456 R459 S521 Q522 D524 S590 D630
BS04	GTP	A	N83 N143 R184 H185 Y189	N82 N142 R183 H184 Y188

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006351 DNA-templated transcription
• GO:0019079 viral genome replication

Cellular Component

• GO:0044423 virion component

External links

• PDB: RCSB:6ogz, PDBe:6ogz, PDBj:6ogz
• PDBsum: 6ogz
• PubMed: 31101900
• UniProt: G0YZJ9