Structure of PDB 6ofd Chain A

Receptor sequence
>6ofdA (length=426) Species: 3885 (Phaseolus vulgaris) [Search protein sequence]
NKNRDMPLDSDVFRVPPGYNAPQQVHITQGDLVGRAMIISWVTMDEPGSS
AVRYWSEKNGRKRIAKGKMSTYRFFNYSSGFIHHTTIRKLKYNTKYYYEV
GLRNTTRRFSFITPPQTGLDVPYTFGLIGDLGQSFDSNTTLSHYELSPKK
GQTVLFVGDLSYADRYPNHDNVRWDTWGRFTERSVAYQPWIWTAGNHEIE
FAPEINETEPFKPFSYRYHVPYEASQSTSPFWYSIKRASAHIIVLSSYSA
YGRGTPQYTWLKKELRKVKRSETPWLIVLMHSPLYNSYNHHFMEGEAMRT
KFEAWFVKYKVDVVFAGHVHAYERSERVSNIAYKITNGLCTPVKDQSAPV
YITIGDAGNYGVIDSNMIQPQPEYSAFREASFGHGMFDIKNRTHAHFSWN
RNQDGVAVEADSVWFFNRHWYPVDDS
3D structure
PDB6ofd Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D135 D164 Y167 N201 H202 H286 H295 H296 H323 H325
Catalytic site (residue number reindexed from 1) D130 D159 Y162 N196 H197 H281 H290 H291 H318 H320
Enzyme Commision number 3.1.3.2: acid phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D164 N201 H286 H323 D159 N196 H281 H318
BS02 FE A D135 D164 Y167 H325 D130 D159 Y162 H320
BS03 MF1 A K7 R9 R170 N201 H202 H295 H296 H325 Y365 V367 K2 R4 R165 N196 H197 H290 H291 H320 Y360 V362 MOAD: Ki=0.5uM
Gene Ontology
Molecular Function
GO:0003993 acid phosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6ofd, PDBe:6ofd, PDBj:6ofd
PDBsum6ofd
PubMed31445230
UniProtP80366|PPAF_PHAVU Fe(3+)-Zn(2+) purple acid phosphatase

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