Structure of PDB 6oeb Chain A

Receptor sequence
>6oebA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
CGRTSCHLPRDVLTRACAYQDRRGQQRLPEWRDPDKYCPSYNKSPQSNSP
VLLSRLHFEKDADSSERIIAPMRWGLVPSWFKESDPSKLQFNTTNCRSDT
VMEKRSFKVPLGKGRRCVVLADGFYEWQRCQGTNQRQPYFIYFPQIKPEN
WEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRM
PAILDGEEAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNT
PECLAPV
3D structure
PDB6oeb Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.-.-
4.-.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A W81 F92 N93 N96 R98 K105 R106 S107 T199 H210 R212 W80 F91 N92 N95 R97 K104 R105 S106 T186 H197 R199 PDBbind-CN: Kd=720nM
BS02 dna A W81 R106 K109 W80 R105 K108 PDBbind-CN: Kd=720nM
Gene Ontology
Molecular Function
GO:0003697 single-stranded DNA binding
Biological Process
GO:0006974 DNA damage response
GO:0106300 protein-DNA covalent cross-linking repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6oeb, PDBe:6oeb, PDBj:6oeb
PDBsum6oeb
PubMed31235913
UniProtQ96FZ2|HMCES_HUMAN Abasic site processing protein HMCES (Gene Name=HMCES)

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