Structure of PDB 6ob3 Chain A

Receptor sequence
>6ob3A (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGAGDVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKEK
3D structure
PDB6ob3 KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis.
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A D13 G15 K16 S17 A18 F28 D30 P34 T35 G60 N116 K117 D119 S145 A146 K147 D14 G16 K17 S18 A19 F29 D31 P35 T36 G61 N117 K118 D120 S146 A147 K148
BS02 MG A S17 T35 S18 T36
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ob3, PDBe:6ob3, PDBj:6ob3
PDBsum6ob3
PubMed31611389
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

[Back to BioLiP]