Structure of PDB 6oa0 Chain A

Receptor sequence
>6oa0A (length=501) Species: 9606 (Homo sapiens) [Search protein sequence]
DKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFP
THYKDLWDNKHVKMPCSEQNLYPVTAGSRWELIQTALLNKFTRPQNLKDA
ILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPN
ICTQPIPLLAAAMNHSITMSQEQIASLLANAFFCTFPRRNASSYPDINFN
RLFEGRSSRKPEKLKTLFCYFRRVTAAAPTGLVTFTRQSLEDFPEWERCE
KPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLIN
PELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERD
DWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENL
SAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIY
SMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVES
C
3D structure
PDB6oa0 Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M1D A Y795 F902 Y333 F440
Gene Ontology
Molecular Function
GO:0004649 poly(ADP-ribose) glycohydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006282 regulation of DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6oa0, PDBe:6oa0, PDBj:6oa0
PDBsum6oa0
PubMed31827085
UniProtQ86W56|PARG_HUMAN Poly(ADP-ribose) glycohydrolase (Gene Name=PARG)

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