Structure of PDB 6o8e Chain A

Receptor sequence

>6o8eA (length=592) Species: 1395 ([Bacillus] caldotenax)

EGRFQLVAPYEPQGDQPQAIAKLVDGLRRGVKHQTLLGATGTGKTFTISN
VIAQVNKPTLVIAHNKTLAGQLYSELKEFFPHNAVEYFVSYYDYYQPEAY
VPQTDTYIEKDAKINDEIDKLRHSATSALFERRDVIIVASVSSIYGLGSP
EEYRELVVSLRVGMEIERNALLRRLVDIQYDRNDIDFRRGTFRVRGDVVE
IFPASRDEHSIRVEFFGDEIERIREVDALTGEVLGEREHVAIFPASHFVC
REEKMRLAIQNIEQELEERLAELRAQGKLLEAQRLEQRTRYDLEMMREMG
FSSGIENYSRHLALRPPGSTPYTLLDYFPDDFLIIVDESHVTLPQLRGMY
NGDRARKQVLVDHGFRLPSALDNRPLTFEEFEQKINQIIYVSATPGPYEL
EHSPGVVEQIIRPTGLLDPTIDVRPTKGQIDDLIGEIRERVERNERTLVT
TLTKKMAEDLTDYLKEAGIKVAYLHSEIKTLERIEIIRDLRLGKYDVLVG
INLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNANGHVIM
YADTITKSMEIAIQETKRRRAIQEEYNRKHGIVPRTVKKEIR

3D structure

• PDB: 6o8e Mechanism of DNA Lesion Homing and Recognition by the Uvr Nucleotide Excision Repair System.
• Chain: A
• Resolution: 2.61 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	N66 K67 S91 Y92 Y93 Y96 A113 S141 S143 Y146 F249 F302 S304 G305 E307 Q346 M350 T454 K455 H476 S477 R484 I502 N503 L504 F527	N65 K66 S90 Y91 Y92 Y95 A112 S140 S142 Y145 F248 F301 S303 G304 E306 Q345 M349 T453 K454 H475 S476 R483 I501 N502 L503 F526
BS02	dna	A	Y95 Q97 P98 D112 E299 P345 G349 G353 A356 E525 F527	Y94 Q96 P97 D111 E298 P344 G348 G352 A355 E524 F526
BS03	ADP	A	Y11 E12 P13 Q14 Q17 T41 G42 G44 K45 P414 R543	Y10 E11 P12 Q13 Q16 T40 G41 G43 K44 P413 R542

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006289 nucleotide-excision repair

Cellular Component

• GO:0009380 excinuclease repair complex

External links

• PDB: RCSB:6o8e, PDBe:6o8e, PDBj:6o8e
• PDBsum: 6o8e
• PubMed: 31549070
• UniProt: P56981|UVRB_BACCA UvrABC system protein B (Gene Name=uvrB)