Structure of PDB 6o74 Chain A

Receptor sequence

>6o74A (length=704) Species: 342948 (Thermococcus onnurineus) [Search protein sequence]

MEIDELTALGGLLHDIGKPVQRAGLYSGDHSTQGARFLRDLAENTGRAEY
ELLSLFSEFHNDELMIRRIKELSPERFGLTMEDVLNALWIVYEADNLASP
QASRPLYSVFNPGKAYPWAELDFEKELPVPGDVFSIRSQDYRELVKRLWE
ELSKAKLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMTSAIALAML
RAGCAEGRCRKEKRFLLIEGDFSGIQDFIYRVSTLKYLRARSAYLELIGW
DVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPDAVKELEEIRAKAVEWL
YREFESDLYLAIEWEPVSGREFGREGNLFAEARKRLKHKLTVRKLKRFGE
IKGLFECNRLVSLPKLLGFGRTAKNDAGVLVEGPFSGFVPYLQGGRPVGE
QILVKNTLNPGEIPESAQFVPYFVADYFKKDPKGGVATFEELSMASTGTR
RLGVMKGDVDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGAIIEGKFGY
IIGDVPSLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRVRRAFNAY
TGGKLTLSVGLGYFDERTPIYRMADVVSERLDTAKDEGRNRVFVVGRSRP
LDGKHKLSYEWNHYEELWRTYAPRIYAGNGRLKGKLESKKGLLWKLLEIR
ELYVRDPNDVRWAYLTSDLFPELVGIDTKAVERKEPQPVYWVDGVLKIVL
MAVR

3D structure

PDB

6o74 Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.

Chain

Resolution

2.71 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.-
3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ANP	A	F290 H295 D521 V522 R524 L525 G526 F529 S542 D546 G587 D588 K648 R652	F269 H274 D458 V459 R461 L462 G463 F466 S479 D483 G524 D525 K585 R589
BS02	ANP	A	S241 G242 I243 I247 S263 L266 G293 K367 Y584 D589	S223 G224 I225 I229 S242 L245 G272 K344 Y521 D526
BS03	MN	A	D521 V522 D588	D458 V459 D525
BS04	MN	A	D521 D588 D589	D458 D525 D526
BS05	MN	A	D239 F240	D221 F222

Gene Ontology

	Molecular Function
GO:0004519	endonuclease activity
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0042802	identical protein binding

	Biological Process
GO:0051607	defense response to virus

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6o74, PDBe:6o74, PDBj:6o74
PDBsum	6o74
PubMed	31326272
UniProt	B6YWB8\|CAS10_THEON CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=csm1)

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