Structure of PDB 6o5f Chain A

Receptor sequence
>6o5fA (length=417) Species: 9606 (Homo sapiens) [Search protein sequence]
DDWSKPLPPSERLEQELFKYDDIPVEATGNNCPPHIESFSDVEMGEIIMG
NIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIY
SDGPGEALRAMKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYG
GADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRM
LDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIF
LAVENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLED
FLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARSNVKHV
INFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEA
KQEVPSWLENMAYEHHY
3D structure
PDB6o5f The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X.
ChainA
Resolution2.504 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A S181 T201 R202 E449 T450 K451 H472 G473 R480 T498 V500 H578 H579 S38 T58 R59 E290 T291 K292 H313 G314 R321 T339 V341 H415 H416
BS02 rna A E180 S520 D521 N551 E37 S357 D358 N388
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6o5f, PDBe:6o5f, PDBj:6o5f
PDBsum6o5f
PubMed31300642
UniProtO00571|DDX3X_HUMAN ATP-dependent RNA helicase DDX3X (Gene Name=DDX3X)

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