Structure of PDB 6o3p Chain A

Receptor sequence
>6o3pA (length=308) Species: 10090 (Mus musculus) [Search protein sequence]
SHMLDRRSDKRNNSDWLQAKESHPTTVYLLFSDLNPLVTLGGNKESSQQP
EVRLCQLNYPDVKGYLAQPEKITLVFLGVELDGLVAWFALGIEPGAAENC
YFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCPTCGSATKIEEGG
YKRVCVRETCPSLQGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPP
GMFTCLAGFIEPGETIEDAVRREVEEESGVKVGHVQYVSCQPWPMPSSLM
IGCLAVAVSTEIKVDKNEIEDARWFTREQVVDVLTKGQAFFVPPSRAIAH
QLIKHWVG
3D structure
PDB6o3p Structural and mechanistic basis of mammalian Nudt12 RNA deNADding.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
3.6.1.22: NAD(+) diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A D322 G355 F356 E370 E415 D175 G208 F209 E223 E268
BS02 MG A A354 E374 E415 A207 E227 E268
BS03 MG A E370 E374 E415 E223 E227 E268
BS04 ZN A C284 C287 C302 C307 C137 C140 C155 C160
BS05 AMP A V313 N315 Y318 V166 N168 Y171
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6o3p, PDBe:6o3p, PDBj:6o3p
PDBsum6o3p
PubMed31101919
UniProtQ9DCN1|NUD12_MOUSE NAD-capped RNA hydrolase NUDT12 (Gene Name=Nudt12)

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