Structure of PDB 6o3c Chain A

Receptor sequence
>6o3cA (length=484) Species: 10090 (Mus musculus) [Search protein sequence]
LSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWS
GLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERE
RGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDV
EGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSN
RYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTSSE
TLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGL
VLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAF
GFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGDCEIKNRPSLLVE
KINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRL
3D structure
PDB6o3c Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LKD A N223 M305 D388 Y398 D477 W484 E485 F488 E522 N159 M241 D324 Y334 D413 W420 E421 F424 E450
BS02 CLR A F395 T470 N525 M529 T532 F331 T406 N453 M457 T460
BS03 CLR A D99 L112 W113 D35 L48 W49
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6o3c, PDBe:6o3c, PDBj:6o3c
PDBsum6o3c
PubMed31263273
UniProtP56726|SMO_MOUSE Protein smoothened (Gene Name=Smo)

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