Structure of PDB 6o36 Chain A

Receptor sequence
>6o36A (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDRTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHKE
3D structure
PDB6o36 GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A G13 G15 K16 S17 A18 F28 D30 G60 Q61 N116 K117 D119 L120 S145 A146 G13 G15 K16 S17 A18 F28 D30 G60 Q61 N116 K117 D119 L120 S145 A146
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6o36, PDBe:6o36, PDBj:6o36
PDBsum6o36
PubMed32187889
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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