Structure of PDB 6o12 Chain A

Receptor sequence
>6o12A (length=405) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
IFSVDKVRADFPVLSREVNGLPLAYLDSAASAQKPSQVIDAEAEFYRHGY
AAVHRGIHTLSAQATEKMENVRKRASLFINARSAEELVFVRGTTEGINLV
ANSWGNSNVRAGDNIIISQMEAHANIVPWQMLCARVGAELRVIPLNPDGT
LQLETLPTLFDEKTRLLAITHVSNVLGTENPLAEMITLAHQHGAKVLVDG
AQAVMHHPVDVQALDCDFYVFSGHKLYGPTGIGILYVKEALLQEMPPWEG
GGSMIATVSLSEGTTWTKAPWRFEAGTPNTGGIIGLGAALEYVSALGLNN
IAEYEQNLMHYALSQLESVPDLTLYGPQNRLGVIAFNLGKHHAYDVGSFL
DNYGIAVRTGHHCAMPLMAYYNVPAMCRASLAMYNTHEEVDRLVTGLQRI
HRLLG
3D structure
PDB6o12 Direct observation of intermediates in the SufS cysteine desulfurase reaction reveals functional roles of conserved active-site residues.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.1.7: cysteine desulfurase.
3.13.1.-
4.4.1.16: selenocysteine lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A T94 T95 D200 A202 Q203 S223 H225 K226 T93 T94 D199 A201 Q202 S222 H224 K225
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008826 cysteine sulfinate desulfinase activity
GO:0009000 selenocysteine lyase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001887 selenium compound metabolic process
GO:0006534 cysteine metabolic process
GO:0006790 sulfur compound metabolic process
GO:0016226 iron-sulfur cluster assembly
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:6o12, PDBe:6o12, PDBj:6o12
PDBsum6o12
PubMed31248989
UniProtP77444|SUFS_ECOLI Cysteine desulfurase (Gene Name=sufS)

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