Structure of PDB 6nzv Chain A

Receptor sequence
>6nzvA (length=191) [Search protein sequence]
KGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGEVQIVST
ATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLVGWQAP
QGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGS
SGGPLLCPAGHAVGIFRAAVSTRGVAKAVQFIPVESLETTM
3D structure
PDB6nzv Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L9J A Q1041 F1043 H1057 V1078 D1081 R1123 L1135 G1137 S1139 F1154 R1155 A1156 A1157 Q53 F55 H69 V90 D93 R135 L147 G149 S151 F166 R167 A168 A169 PDBbind-CN: -logKd/Ki=10.17,Ki=0.067nM
BS02 ZN A C1097 C1099 C1145 C109 C111 C157
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6nzv, PDBe:6nzv, PDBj:6nzv
PDBsum6nzv
PubMed31133531
UniProtS4UY05

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