Structure of PDB 6nxg Chain A

Receptor sequence

>6nxgA (length=385) Species: 126793 (Plasmodium vivax Sal-1)

PDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYV
CDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTW
HIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLA
PVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIG
FSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQF
NLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGND
KYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSV
FEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL

3D structure

• PDB: 6nxg Identification of Selective Inhibitors ofPlasmodiumN-Myristoyltransferase by High-Throughput Screening.
• Chain: A
• Resolution: 1.6 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	L169 K172 L174	L144 K147 L149
BS02	L7Y	A	V96 D98 F105 Y211 H213 F226 L330 Y334 N365 A366	V71 D73 F80 Y186 H188 F201 L305 Y309 N340 A341
BS03	MYA	A	Y28 F30 W31 Y95 V96 L163 C164 V165 R170 S171 R173 A175 T183 I186 W192 Q193 A194 Y196 T197 L202 Y393	Y3 F5 W6 Y70 V71 L138 C139 V140 R145 S146 R148 A150 T158 I161 W167 Q168 A169 Y171 T172 L177 Y368

Gene Ontology

Molecular Function

• GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006499 N-terminal protein myristoylation
• GO:0018008 N-terminal peptidyl-glycine N-myristoylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6nxg, PDBe:6nxg, PDBj:6nxg
• PDBsum: 6nxg
• PubMed: 31850752
• UniProt: A5K1A2