Structure of PDB 6nwl Chain A

Receptor sequence
>6nwlA (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
FPTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKWA
KALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLV
INEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKD
GLKSQAVFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEM
VGGLLQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQK
3D structure
PDB6nwl First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-ActivatedgammaCoactivator 1-alphaComplex with Endogenous and Synthetic Glucocorticoids.
ChainA
Resolution1.595 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V44 K48 L58 M62 E224 V47 K51 L61 M65 E227
BS02 HCY A M29 L32 N33 G36 Q39 M70 F92 Q111 F204 C205 T208 M32 L35 N36 G39 Q42 M73 F95 Q114 F207 C208 T211 MOAD: Ki=43nM
PDBbind-CN: -logKd/Ki=7.37,Ki=43nM
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