Structure of PDB 6nw7 Chain A

Receptor sequence
>6nw7A (length=216) Species: 36809 (Mycobacteroides abscessus) [Search protein sequence]
GSMKIDVVTIFPEYLQPVRQSLPGKAIDAGLVDVAVHDLRRWTHDVHKSV
DDSPYGGGPGMVMKPTVWGDALDEICTSETLLVVPTPAGYPFTQETAWQW
STEDHLVIACGRYEGIDQRVADDAATRMRVREVSIGDYVLNGGEAAALVI
IEAVLRLVPGVLGNASLLEGPSYTRPPSWRGMDVPPVLLSGDHAKIAAWR
AEQSRQRTIERRPDLL
3D structure
PDB6nw7 Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
ChainA
Resolution1.481 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P85 E112 R154
Catalytic site (residue number reindexed from 1) P87 E114 R156
Enzyme Commision number 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A P83 T84 P85 G109 Y111 E112 S132 I133 L138 G140 G141 P85 T86 P87 G111 Y113 E114 S134 I135 L140 G142 G143
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6nw7, PDBe:6nw7, PDBj:6nw7
PDBsum6nw7
PubMed32602532
UniProtB1MDI3

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