Structure of PDB 6nuu Chain A

Receptor sequence
>6nuuA (length=361) Species: 9606 (Homo sapiens) [Search protein sequence]
KLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEES
VALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPA
NTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRALTEA
FTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTL
DDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYF
YSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAP
NYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGE
KVTEMLVNVLN
3D structure
PDB6nuu Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F299 N327 V328 M329 N330 I331 Q333 P344 W352 S353 F356 F290 N318 V319 M320 N321 I322 Q324 P335 W343 S344 F347
BS02 FE A D90 H92 D118 D81 H83 D109
BS03 ZN A D118 N150 H199 H281 D109 N141 H190 H272
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0033192 calmodulin-dependent protein phosphatase activity
Biological Process
GO:0097720 calcineurin-mediated signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:6nuu, PDBe:6nuu, PDBj:6nuu
PDBsum6nuu
PubMed31375679
UniProtQ08209|PP2BA_HUMAN Protein phosphatase 3 catalytic subunit alpha (Gene Name=PPP3CA)

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