Structure of PDB 6nuq Chain A

Receptor sequence
>6nuqA (length=522) Species: 9606 (Homo sapiens) [Search protein sequence]
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKNQSVT
RQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRR
QQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGD
PIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFT
TKVRLLVKFPELNYQLKIKVCIDKDRGSRKFNILGTNTKVMNMEESNNGS
LSAEFKHLTLREQRLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVIS
NICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSST
TKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWL
DNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSK
EGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNI
LVSPLVYLYPDIPKEEAFGKYC
3D structure
PDB6nuq A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
ChainA
Resolution3.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KQV A R609 S611 E612 S613 S636 V637 E638 P639 Y640 Q644 Y657 K658 R444 S446 E447 S448 S471 V472 E473 P474 Y475 Q479 Y492 K493 BindingDB: Ki=14nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6nuq, PDBe:6nuq, PDBj:6nuq
PDBsum6nuq
PubMed31715132
UniProtP40763|STAT3_HUMAN Signal transducer and activator of transcription 3 (Gene Name=STAT3)

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