Structure of PDB 6nt3 Chain A

Receptor sequence
>6nt3A (length=1278) Species: 6978,9606 [Search protein sequence]
ANKDRDGSAHPDQALEQGSRLPARMRNIFPAELASNKKTFVVVTKASGEK
SLWMLDPFTPIRRVAISTMVQPIFSYFIMITILIHCIFMIMPATQTTYIL
ELVFLSIYTIEVVVKVLARGFILHPFAYLRDPWNWLDFLVTLIGYITLVV
DLGHLYALRAFRVLRSWRTVTIVPGWRTIVDALSLSITSLKDLVLLLLFS
LSVFALIGLQLFMGNLKHKCVKHFPADGSWGNFTDERWFNYTSNSSHWYI
PDDWIEYPLCGNSSGAGMCPPGYTCLQGYGGNPNYGYTSFDTFGWAFLSV
FRLVTLDYWEDLYQLALRSAGPWHILFFIIVVFYGTFCFLNFILAVVVMS
YTHMVKRADEEKAAECVPWQKLQGAIGAVVLSPFFELFIAVIIVLNITFM
ALDHHDMNIEFERILRTGNYIFTSIYIVEAVLKIIALSPKFYFKDSWNVF
DFIIVVFAILELGLEGVQGLSVFRSFRLLRVFRLAKFWPTLNNFMSVMTK
SYGAFVNVMYVMFLLLFIFAIIGMQLFGMNYIDNMERFPDGDLPRWNFTD
FLHSFMIVFRALCGEWIESMWDCMLVGDWSCIPFFVAVFFVGNLVILNLL
IALLLNNYGSVQRMWSNIRRVCFLLAKNKYFQKFVTAVLVITSVLLALED
IYLPQRPVLVNITLYVDYVLTAFFVIEMIIMLFAVGFKKYFTSKWYWLDF
IVVVAYLLNFVLMCAGIEALQTLRLLRVFRLFRPLSKVNGMQVVTSTLVE
AVPHIFNVILVGIFFWLVFAIMGVQLFAGKFYKCVDENSTVLSHEITMDR
NDCLHENYTWENSPMNFDHVGNAYLSLLQVATFKGWLQIMNDAIDSREVH
KQPIRETNIYMYLYFIFFIVFGSFFILKLFVCILIDIFRQQRRKAEGLSA
TDSRTQLIYRRAVMRTMSAKPVKRIPKPGNKIQGCIFDLVTNQAFDISIM
VLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHY
YFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILR
LVKGAKGIRLLLLALRKALRTLFNVSFLLFVIMFVYAVFGMEFFMHIRDA
GAIDDVYNFKTFGQSIILLFQLATSAGWDGVYFAIANEEDCRAPDHELGY
PGNCGSRALGIAYLVSYLIITCLVVINMYAAVILDYVLEVYEDSKEGLTD
DDYDMFFEVWQQFDPEATQYIRYDQLSELLEALQPPLQVQKPNKYKILSM
NIPICKDDHIFYKDVLEALVKDVFSRRG
3D structure
PDB6nt3 Cryo-EM structures of a human-cockroach hybrid Nav channel in the presence and absence of the alpha-scorpion toxin AaH2.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 76F A K921 W922 F956 F959 K694 W695 F729 F732
BS02 76F A H1046 R1384 H819 R1157
BS03 76F A W363 F365 W715 W295 F297 W579
BS04 AJP A M999 R1074 N1085 Y1091 F1094 M772 R847 N858 Y864 F867
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 monoatomic cation channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6nt3, PDBe:6nt3, PDBj:6nt3
PDBsum6nt3
PubMed
UniProtD0E0C2|SCNA1_PERAM Sodium channel protein PaFPC1;
Q15858|SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (Gene Name=SCN9A)

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