Structure of PDB 6nr5 Chain A

Receptor sequence
>6nr5A (length=636) Species: 9606 (Homo sapiens) [Search protein sequence]
GVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWL
DNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKP
LPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRK
GNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPK
EKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKH
VKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQTAEFLVKSKHR
DLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFAN
LEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIK
LNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPP
AVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTT
ASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIF
GSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPPIP
RLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL
3D structure
PDB6nr5 Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.99.66: [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KXM A G285 G287 S289 L307 E308 A309 R310 G315 R316 G330 A331 V333 V590 L625 W756 S760 Y761 G800 E801 A809 T810 V811 A814 G113 G115 S117 L135 E136 A137 R138 G143 R144 G158 A159 V161 V405 L440 W571 S575 Y576 G606 E607 A615 T616 V617 A620
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:6nr5, PDBe:6nr5, PDBj:6nr5
PDBsum6nr5
PubMed31249575
UniProtO60341|KDM1A_HUMAN Lysine-specific histone demethylase 1A (Gene Name=KDM1A)

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