Structure of PDB 6npy Chain A

Receptor sequence
>6npyA (length=798) Species: 9606 (Homo sapiens) [Search protein sequence]
IYCAKYRAYVRSRFQCIESLNKRYTRLRLIKEHRIKMELLFDPDDEHSEP
VHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVT
QRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPL
CTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHV
EILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIV
CTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGLCAHLWGLCSLA
ADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHM
TFQEFFAAMYYLLENVPGSRLKLPSRENYGKFEKGYLIFVVRFLFGLVNQ
ERTAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEIGFLHNMP
KEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLS
TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCF
DISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCC
LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQK
LGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLH
PDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMM
FCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW
3D structure
PDB6npy Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.
ChainA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R165 Y166 T167 G229 K230 T231 I232 Y379 L411 W414 H520 R23 Y24 T25 G63 K64 T65 I66 Y213 L245 W248 H349
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0030674 protein-macromolecule adaptor activity
GO:0035591 signaling adaptor activity
GO:0042802 identical protein binding
GO:0042834 peptidoglycan binding
GO:0043531 ADP binding
GO:0043565 sequence-specific DNA binding
GO:0060090 molecular adaptor activity
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0140297 DNA-binding transcription factor binding
GO:0140299 molecular sensor activity
GO:0140608 cysteine-type endopeptidase activator activity
GO:0140693 molecular condensate scaffold activity
GO:1901981 phosphatidylinositol phosphate binding
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0002674 negative regulation of acute inflammatory response
GO:0002830 positive regulation of type 2 immune response
GO:0006915 apoptotic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007231 osmosensory signaling pathway
GO:0009595 detection of biotic stimulus
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032753 positive regulation of interleukin-4 production
GO:0044546 NLRP3 inflammasome complex assembly
GO:0045087 innate immune response
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051260 protein homooligomerization
GO:0051604 protein maturation
GO:0070269 pyroptotic inflammatory response
GO:0071222 cellular response to lipopolysaccharide
GO:0098586 cellular response to virus
GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction
GO:2000553 positive regulation of T-helper 2 cell cytokine production
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0031021 interphase microtubule organizing center
GO:0061702 canonical inflammasome complex
GO:0072559 NLRP3 inflammasome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6npy, PDBe:6npy, PDBj:6npy
PDBsum6npy
PubMed31189953
UniProtQ96P20|NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 (Gene Name=NLRP3)

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