Structure of PDB 6nph Chain A

Receptor sequence
>6nphA (length=472) Species: 7955 (Danio rerio) [Search protein sequence]
KFGWIKGVLVRCMLNIWGVMLFIRMTWIVGQAGIAYSCIIVIMATVVTTI
TGCSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMY
VVGFAETVVELLMDSGLLMIDQTNDIRVIGTITVILLLGISVAGMEWEAK
AQIFLLVILITAIFNYFIGSFIAVDSKKKFGFFSYDAGILAENFGPDFRG
QTFFSVFSIFFPAATGILAGANISGDLADPQMAIPKGTLLAILITGLVYV
GVAISAGACIVRDATGIESNFTLISNCTDAACKYGYDFSSCRPTVEGEVS
SCKFGLHNDFQVMSVVSGFSPLISAGIFSATLSSALASLVSAPKVFQALC
KDNIYPGIAIFGKGYGKNNEPLRGYFLTFGIALAFILIAELNVIAPIISN
FFLASYALINFSVFHASLANSPGWRPSFKYYNMWASLAGAILCCVVMFII
NWWAALLTNVIVLSLYIYVSYK
3D structure
PDB6nph Structure and mechanism of the cation-chloride cotransporter NKCC1.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K A N220 I221 G223 Y305 P417 A418 T420 N15 I16 G18 Y100 P212 A213 T215
BS02 CL A G421 L423 G216 L218
Gene Ontology
Molecular Function
GO:0015377 chloride:monoatomic cation symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6nph, PDBe:6nph, PDBj:6nph
PDBsum6nph
PubMed31367042
UniProtA0A0G2KTI4|S12A2_DANRE Solute carrier family 12 member 2 (Gene Name=slc12a2)

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