Structure of PDB 6nk1 Chain A

Receptor sequence
>6nk1A (length=181) Species: 9606 (Homo sapiens) [Search protein sequence]
GEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGD
QDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAES
DLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRK
GFYLAFQDIGACVALLSVRVYYKKAHHHHHH
3D structure
PDB6nk1 Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E40 L54 M55 Q56 N57 Y65 M66 C70 R103 F108 F156 R159 V161 C188 V189 E14 L28 M29 Q30 N31 Y39 M40 C44 R77 F82 F130 R133 V135 C162 V163
BS02 peptide A N133 Q135 R137 N107 Q109 R111
External links
PDB RCSB:6nk1, PDBe:6nk1, PDBj:6nk1
PDBsum6nk1
PubMed31015204
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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