Structure of PDB 6nk0 Chain A

Receptor sequence
>6nk0A (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
GEVVLLDFAAAGGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDN
WLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLD
YGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFY
LAFQDIGACVALLSVRVYYKKAHHHHHH
3D structure
PDB6nk0 Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
ChainA
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L54 M55 Q56 N57 Y65 M66 C70 R103 F108 F156 R159 V161 C188 V189 L25 M26 Q27 N28 Y36 M37 C41 R74 F79 F127 R130 V132 C159 V160
BS02 ACA A D78 K136 F139 D49 K107 F110
External links
PDB RCSB:6nk0, PDBe:6nk0, PDBj:6nk0
PDBsum6nk0
PubMed31015204
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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