Structure of PDB 6njz Chain A

Receptor sequence
>6njzA (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
GEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGD
QDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAES
DLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRK
GFYLAFQDIGACVALLSVRVYYKKAHHHH
3D structure
PDB6njz Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L54 M55 Q56 N57 M59 Y65 M66 C70 R103 F108 F156 R159 V161 C188 V189 L28 M29 Q30 N31 M33 Y39 M40 C44 R77 F82 F130 R133 V135 C162 V163
External links
PDB RCSB:6njz, PDBe:6njz, PDBj:6njz
PDBsum6njz
PubMed31015204
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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