Structure of PDB 6njs Chain A

Receptor sequence
>6njsA (length=523) Species: 9606 (Homo sapiens) [Search protein sequence]
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKNQSVT
RQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRR
QQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGD
PIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFT
TKVRLLVKFPELNYQLKIKVCIDKDRGSRKFNILGTNTKVMNMEESNNGS
LSAEFKHLTLREQRCLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVI
SNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSS
TTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVW
LDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESS
KEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATN
ILVSPLVYLYPDIPKEEAFGKYC
3D structure
PDB6njs A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KQV A R609 S611 E612 S613 S636 V637 E638 P639 Y640 Q644 Y657 R445 S447 E448 S449 S472 V473 E474 P475 Y476 Q480 Y493 BindingDB: Ki=14nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6njs, PDBe:6njs, PDBj:6njs
PDBsum6njs
PubMed31715132
UniProtP40763|STAT3_HUMAN Signal transducer and activator of transcription 3 (Gene Name=STAT3)

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