Structure of PDB 6nfz Chain A

Receptor sequence
>6nfzA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
DIFNRDPRDHYDLLQRLGTYGEVFKARDKVSGDLVALKMVTLQKEILILK
TCRHANIVAYHGSYLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVL
QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSF
IGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLR
VLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQ
LVSQPGLNRGLILDLLDKLK
3D structure
PDB6nfz Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation.
ChainA
Resolution2.966 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 A141 N142 D155 A164 T175
Catalytic site (residue number reindexed from 1) D115 K117 A119 N120 D133 A142 T153
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B49 A L23 V31 M91 C94 G95 G97 D101 L144 L17 V23 M69 C72 G73 G75 D79 L122 PDBbind-CN: -logKd/Ki=7.80,Kd=16nM
BindingDB: Kd=16nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6nfz, PDBe:6nfz, PDBj:6nfz
PDBsum6nfz
PubMed31018963
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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