Structure of PDB 6nff Chain A

Receptor sequence

>6nffA (length=794) Species: 1587 (Lactobacillus helveticus)

HMKYNQYAYVETDFQQQVKELIDINFLPKNYQVWDFGSLLAKLVKNAIAE
AKTDAAKNAKLAEFAVSDHQTLADFLKEKPTEIGTKQFYNVALQLLGYHV
HYDYDFADPTGFMQRNALPFLQDISDNQKLISAFYRLLNTRAKNGQILLD
VMAGKGYFTQFWGQNKFKFFNGKSIPVFDTNKVIREVVYVETDLDTDHDG
KSDLIQVTVFRPEETNKGLKVPALYTASPYFGGIIANEKRNHNVDENLSD
STEWNDPQYVHSPIVKAEKPDGSSRPATEEAVHKSSYPLNEYMLARGFAS
VFAGAIGTRGSDGVRITGAPEETESAAAVIEWLHGDRVAYTDRTRTVRTT
ADWCNGNIGMTGRSYLGTLQIAIATTGVKGLKTVVSEAAISSWYDYYREH
GSVIAPEACQGEDLDLLAETCQSNLWDAGSYLKIKPEYDKMQKQLREKED
RNTGQYSDFWEAGNYRHHADGIKCSWISVHGLNDWNVKPKNVYKIWQLVK
KMPMKHHLFLHQGPHYNMNNLVSIDFTDLMNLWFVHELLGIENNAYNQWP
TVMIQDNLQADKWHEEPDWSNDLGQEKIYYPTDEGELFQDGNGKAQKSFT
DVGGIEFKKAGISESDWQYKFICGDEKWAKPSLRFETDEFTHPTTIVGRP
EVKVRVSASLPKGEISVALVELGERQRLTATPKFLMHGGQELGYRFGTDT
LQEFVPDKKTKAKLITKAHMNLQNFKDMKKPEAIDADKFYDLDFLLQPTY
YTIPSGSKLALIIYSTDQGMTKRPLEDETYTIDLANTEIKFYEK

3D structure

• PDB: 6nff Structural characterization of a prolyl aminodipeptidase (PepX) from Lactobacillus helveticus.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 3.4.14.11: Xaa-Pro dipeptidyl-peptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	D194 D196 D198 K200 D202	D195 D197 D199 K201 D203
BS02	PO4	A	H399 K493 R648	H400 K494 R649
BS03	PO4	A	R465 H466 K493	R466 H467 K494

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0008239 dipeptidyl-peptidase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6nff, PDBe:6nff, PDBj:6nff
• PDBsum: 6nff
• PubMed: 31584010
• UniProt: Q59485|PEPX_LACHE Xaa-Pro dipeptidyl-peptidase (Gene Name=pepX)