Structure of PDB 6nfa Chain A

Receptor sequence
>6nfaA (length=386) Species: 9606 (Homo sapiens) [Search protein sequence]
DEIYEDLMRTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKP
QDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVY
GRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPM
QRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETL
RQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKA
LLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ
GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCK
ACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGR
3D structure
PDB6nfa Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H516 C546 C549 C564 H336 C366 C369 C384
BS02 ZN A C529 C532 H554 C557 C349 C352 H374 C377
BS03 9K1 A Y280 G281 C369 T526 L535 L536 G538 T539 Y100 G101 C189 T346 L355 L356 G358 T359
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6nfa, PDBe:6nfa, PDBj:6nfa
PDBsum6nfa
PubMed
UniProtP15498|VAV_HUMAN Proto-oncogene vav (Gene Name=VAV1)

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