Structure of PDB 6new Chain A

Receptor sequence
>6newA (length=389) Species: 9606 (Homo sapiens) [Search protein sequence]
EIYEDLMRSKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFL
KPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFL
VYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMV
PMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNE
TLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLD
KALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQG
AQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTS
CKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRH
3D structure
PDB6new Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C529 C532 H554 C557 C351 C354 H376 C379
BS02 ZN A H516 C546 C549 C564 H338 C368 C371 C386
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6new, PDBe:6new, PDBj:6new
PDBsum6new
PubMed
UniProtP15498|VAV_HUMAN Proto-oncogene vav (Gene Name=VAV1)

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