Structure of PDB 6nel Chain A

Receptor sequence
>6nelA (length=202) Species: 655278 (Influenza A virus (A/Luxembourg/43/2009(H1N1))) [Search protein sequence]
GPLGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVC
FMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSIC
NTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHI
HIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE
RG
3D structure
PDB6nel Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H46 D113 E124 I125
BS02 MN A E80 D108 E85 D113
BS03 KKV A Y24 K34 A37 I38 H41 E80 D108 E119 K134 Y29 K39 A42 I43 H46 E85 D113 E124 K139 MOAD: ic50=11nM
PDBbind-CN: -logKd/Ki=7.96,IC50=11nM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6nel, PDBe:6nel, PDBj:6nel
PDBsum6nel
PubMed30983160
UniProtC6H0Y9

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