Structure of PDB 6nco Chain A

Receptor sequence
>6ncoA (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
QRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKA
YKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGEVQ
AMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQA
3D structure
PDB6nco Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer.
ChainA
Resolution1.707 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KQP A E27 L30 G31 W34 D35 D153 Q156 E4 L7 G8 W11 D12 D130 Q133 MOAD: Kd=30uM
PDBbind-CN: -logKd/Ki=4.52,Kd=30uM
Gene Ontology
Biological Process
GO:0006869 lipid transport
GO:0042157 lipoprotein metabolic process
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:6nco, PDBe:6nco, PDBj:6nco
PDBsum6nco
PubMed30933499
UniProtP02649|APOE_HUMAN Apolipoprotein E (Gene Name=APOE)

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