Structure of PDB 6n7a Chain A

Receptor sequence
>6n7aA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPHI
ADLKKEIEILRNLYHENIVKYKGICTGIKLIMEFLPSGSLKEYLPKNKNK
INLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGL
TKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHEL
LTYCDSDSSPMALFLKMIGHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQ
LMRKCWEFQPSNRTSFQNLIEGFEALLK
3D structure
PDB6n7a Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
ChainA
Resolution1.33 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1003 R1007 N1008 D1021
Catalytic site (residue number reindexed from 1) D129 R133 N134 D147
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KEV A L881 G882 G887 V889 A906 M956 L959 E966 L1010 G1020 D1021 L17 G18 G23 V25 A42 M82 L85 E92 L136 G146 D147 MOAD: Ki=4.3nM
PDBbind-CN: -logKd/Ki=8.37,Ki=4.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6n7a, PDBe:6n7a, PDBj:6n7a
PDBsum6n7a
PubMed30981576
UniProtP23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 (Gene Name=JAK1)

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