Structure of PDB 6n5f Chain A

Receptor sequence
>6n5fA (length=336) Species: 334564 (Trichoderma reesei QM9414) [Search protein sequence]
MDTSKLKPNDPRVKYETKQIRGKTYSYILGEPAGPKLETVVLVHGWPDMA
FGWRHQIPYLMSLGFQVVAPNMLGYAGTDAPRDLSQFTLKSVSADIAELA
RSFVGQDGQIVLGGHDWGGAVVWRTAYYHPELVKAVFSVCTPLHPLSAEY
KPLEDIVAAGHMLNFKYQLQLKGPDVEARIQGKDMLRRFFRAMFGGRGPN
GEAGFSTSDGVHFDVLDKIGAPPLLDEQELEYYVEQYALQEAPELRGPLN
WYRTRELNAKDEMDRAKNGPPLRFEMPALFVAASKDNALPPAMSKGMDAF
YKDLTRAEVDATHWALTQAGDEVNRVIGEWLNKALG
3D structure
PDB6n5f The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.
ChainA
Resolution1.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KJ1 A D116 W117 Y167 M193 Y252 H313 D116 W117 Y167 M193 Y252 H313 MOAD: ic50=138.8nM
PDBbind-CN: -logKd/Ki=6.86,IC50=138.8nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004301 epoxide hydrolase activity
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:6n5f, PDBe:6n5f, PDBj:6n5f
PDBsum6n5f
PubMed30771398
UniProtG0R7E2

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