Structure of PDB 6n5c Chain A

Receptor sequence
>6n5cA (length=317) Species: 9606 (Homo sapiens) [Search protein sequence]
QIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEEVILNEPVENWP
LCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRREVYSILQ
AEGILLPRYAILNRDPNNPKECNLIEGEDHVEVNGEVFQKPFVEKPVSAE
DHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFMPT
DGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKL
IAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKIL
GNIVMRELAPQFHIPWS
3D structure
PDB6n5c Synthesis of an alpha-phosphono-alpha , alpha-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A R134 V185 K187 H194 L211 E237 F239 M240 D246 D309 L311 D321 N323 R92 V143 K145 H152 L169 E195 F197 M198 D204 D267 L269 D279 N281
BS02 MG A D321 N323 D279 N281
BS03 MG A D309 D321 D267 D279
BS04 MG A S68 F70 I73 S26 F28 I31
BS05 KDJ A K53 K54 R213 K214 K248 R262 S326 K329 K11 K12 R171 K172 K206 R220 S284 K287 PDBbind-CN: -logKd/Ki=6.43,IC50=375nM
Gene Ontology
Molecular Function
GO:0000829 diphosphoinositol pentakisphosphate kinase activity

View graph for
Molecular Function
External links
PDB RCSB:6n5c, PDBe:6n5c, PDBj:6n5c
PDBsum6n5c
PubMed31391889
UniProtO43314|VIP2_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (Gene Name=PPIP5K2)

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