Structure of PDB 6n54 Chain A

Receptor sequence
>6n54A (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
GEPFLIGVSGGTASGKSSVCAKIVQLLGQNRQKQVVILSQDSFYRVLTSE
QKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRKE
ETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDI
SERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLI
VQHIQDILNG
3D structure
PDB6n54 An optimized chemical-genetic method for cell-specific metabolic labeling of RNA.
ChainA
Resolution2.424 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.48: uridine/cytidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KEA A T29 K33 D62 Y65 F83 D84 F114 H117 R166 T12 K16 D41 Y44 F62 D63 F93 H96 R145 PDBbind-CN: -logKd/Ki=7.75,Kd=17.8nM
Gene Ontology
Molecular Function
GO:0004849 uridine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0043771 cytidine kinase activity
Biological Process
GO:0009224 CMP biosynthetic process
GO:0016310 phosphorylation
GO:0044206 UMP salvage
GO:0044211 CTP salvage
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6n54, PDBe:6n54, PDBj:6n54
PDBsum6n54
PubMed32015544
UniProtQ9BZX2|UCK2_HUMAN Uridine-cytidine kinase 2 (Gene Name=UCK2)

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