Structure of PDB 6n3l Chain A

Receptor sequence
>6n3lA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRI
KGEVTLLSRLHHENIVRYYNAWIENVHYLYIQMEYCEASTLRDTIDQGLY
RDTVRLWRLFREILDGLAYIHEKGMIHRNLKPVNIFLDSDDHVKIGDFAA
LYVSPEYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPFPEDFH
AKQKSVISWLLNHDPAKRPTATELLKSELLP
3D structure
PDB6n3l Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode.
ChainA
Resolution2.61 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N848 K850 N853 D866 A904
Catalytic site (residue number reindexed from 1) N129 K131 N134 D147 A149
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KAV A L596 A617 E636 L640 M802 E803 Y804 C805 F855 I864 G865 D866 F867 L13 A34 E53 L57 M83 E84 Y85 C86 F136 I145 G146 D147 F148 PDBbind-CN: -logKd/Ki=7.57,IC50=27nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6n3l, PDBe:6n3l, PDBj:6n3l
PDBsum6n3l
PubMed31620240
UniProtQ9P2K8|E2AK4_HUMAN eIF-2-alpha kinase GCN2 (Gene Name=EIF2AK4)

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