Structure of PDB 6mzq Chain A

Receptor sequence
>6mzqA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
ELPEDPRWELPRDRLVLGKPLGEGQVVLAEAIGLDKDKPNRVTKVAVKML
KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
GNLREYLQARRPPGLEYSYNPSEEQLSSKDLVSCAYQVARGMEYLASKKC
IHRDLAARNVLVTEDNVMKIADFGLPVKWMAPEALFDRIYTHQSDVWSFG
VLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCW
HAVPSQRPTFKQLVEDLDRIVALTSQE
3D structure
PDB6mzq TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D623 A625 R627 N628 D641
Catalytic site (residue number reindexed from 1) D154 A156 R158 N159 D172
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TZ0 A L484 A512 K514 E531 M535 I545 E562 Y563 A564 N568 L630 A640 D641 L21 A46 K48 E65 M69 I79 E96 Y97 A98 N102 L161 A171 D172 MOAD: ic50=3.9nM
PDBbind-CN: -logKd/Ki=8.41,IC50=3.9nM
BindingDB: IC50=3.6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor receptor activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6mzq, PDBe:6mzq, PDBj:6mzq
PDBsum6mzq
PubMed30600916
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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