Structure of PDB 6mzm Chain A

Receptor sequence
>6mzmA (length=445) Species: 9606 (Homo sapiens) [Search protein sequence]
IIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQ
PLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEEN
GPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPG
QLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCP
LFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSH
SESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCA
YYSMIAAEQRLKDAGYGEKSFKIDDEVRTAPWNTTRAFIAAMKGKCLLEV
TGVADPTGCGEGFSYVKIPNKDADLRRLSLKNAKQLLRKFGVPEEEIKKL
SRWEVIDVVRTMSTESVAEHQERYKEECQRIFDLQNKVLSSTEVL
3D structure
PDB6mzm Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
ChainA
Resolution7.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K797 E839 R843 F852 W862 R1022 K210 E252 R256 F265 W275 R402
BS02 dna A K844 R854 G856 R996 K257 R267 G269 R376
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0017025 TBP-class protein binding
Biological Process
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0005669 transcription factor TFIID complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:6mzm, PDBe:6mzm, PDBj:6mzm
PDBsum6mzm
PubMed30442764
UniProtP21675|TAF1_HUMAN Transcription initiation factor TFIID subunit 1 (Gene Name=TAF1)

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